The development of Terminalia chebula Retz. (Combretaceae) in clinical research (2024)

1. World Health Organization . Traditional medicine-growing needs and potential. WHO policy perspectives on medicine, No. 2. WHO/EBM/2002. WHO: Geneva; 2002. [Google Scholar]

2. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 2005;4:206–220. [PubMed] [Google Scholar]

3. CSIR . The wealth of India - A dictionary of indian raw materials and industrial products. Vol X. New Delhi: Publication and Information Directorate, CSIR; 2002. pp. 522–524. [Google Scholar]

4. Varier . A dictionary of Indian raw materials and industrial products. New Delhi: Publications and Information Directorate, Council of Scientific and Industrial Research; 2002. p. 387. [Google Scholar]

5. Khare CP. Indian medicinal plants: An illustrated dictionary. Berlin: Springer-Verlag; 2007. pp. 652–653. [Google Scholar]

6. Govt. of India . The Ayurvedic pharmacopoeia of India. New Delhi: Government of India Ministry of Health and Family Welfare Department of Indian System of Medicine & hom*oeopathy; 2001. p. 47. [Google Scholar]

7. Gupta AK, Tandon N, Sharma M. Quality standards of Indian medicinal plant. New Delhi: Indian Council of Medical Research; 2003. pp. 207–209. [Google Scholar]

8. Sukhdev SH, Deepak M, Joseph GVR, Joseph S, Nagar G. Indian herbal pharmacopoeia. Vol II. Jammu Tawi: IDM, Mumbai and RRL, CSIR; 1999. pp. 154–159. [Google Scholar]

9. Aslokar LV, Kakkar KK, Chakre OJ. New Delhi: Publications and Information's Directorate, CSIR; 1992. Glossary of Indian medicinal plants with active principles. [Google Scholar]

10. Kumar A, Lakshman K, Jayaveera K, Satish K, Tripathi SM. Estimation of rutin and quercetin Terminalia chebula by HPLC. Int J Aesth Antiag Med. 2009;2(1):3. [Google Scholar]

11. Jayaramkumar K. Effect of geographical variation on content of tannic acid, gallic acid, chebulinic acid, and ethyl gallate in Terminalia chebula fruits. Nat Prod. 2006;2(3–4):170–175. [Google Scholar]

12. Juang LJ, Sheu SJ, Lin TC. Determination of hydrolyzable tannins in the fruit of Terminalia chebula by high-performancc liquid chromatography and capillary electrophoresis. J Sep Sci. 2004;27(9):718–724. [PubMed] [Google Scholar]

13. Williumson EN. Major herbs of Ayurveda. London: Churchill Livingstone; 2002. p. 299. [Google Scholar]

14. Tubtimdee C, Shotipruk A. Extraction of phenolics from Terminalia chebula Retz. with water-ethanol and water-propylene glycol and sugaring-out concentration of extracts. Sep Puri Tech. 2011;77(3):339–346. [Google Scholar]

15. Thakur M, Rana RC, Thakur S. Physiochemical evaluation of Terminalia chebula fruits. J Non Timber Forest Prod. 2008;15:37–42. [Google Scholar]

16. Rangsriwong P, Rangkadilok N, Satayavivad J, Goto M, Shotipruk A. Subcritical water extraction of polyphenolic compounds from Terminalia chebula Retz. fruits. Sep Puri Tech. 2009;66:51–56. [Google Scholar]

17. Muhammad S, Khan BA, Akhtar N, Mahmood T, Rasul A, Hussain I, et al.et al. The morphology, extractions, chemical constituents and uses of Terminalia chebula: A review. J Med Plants Res. 2012;6(33):4772–4775. [Google Scholar]

18. Yoganarasimhan SN. Medicinal plants of India. Bangalore: Self Publication; 2000. p. 541. [Google Scholar]

19. Zhang X, Chen C, He S, Ge F. Supercritical-CO2 fluid extraction of the fatty oil in Terminalia chebula and GC-MS analysis. Zhong Yao Cai. 1997;20(9):463–464. [PubMed] [Google Scholar]

20. Mammen D, Bapat S, Sane R. An investigation to variation in constituents in the fruits of Terminalia chebula Retz. at different maturity stages. Int J Pharm Bio Sci. 2012;3(1):416–419. [Google Scholar]

21. Han Q, Song J, Qiao C, Wong L, Xu H. Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography. J Sep Sci. 2006;29(11):1653–1657. [PubMed] [Google Scholar]

22. Bruneton J. Pharmacognosy, phytochemistry, medicinal plants. Paris: Laviosier Publishing; 1995. p. p.333. [Google Scholar]

23. Khare CP. Indian herbal remedies: Rational western therapy, Ayurvedic and other traditional usage, Botany. Berlin: Springer; 2004. pp. 451–452. [Google Scholar]

24. Chang CL, Lin CS. Development of antioxidant activity and pattern recognition of Terminalia chebula Retzius extracts and its fermented products. HungKuang J. 2010;61:115–129. [Google Scholar]

25. Naik GH, Priyadarsini KI, Naik DB, Gangabhagirathi R, Mohan H. Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector. Phytomedicine. 2004;11(6):530–538. [PubMed] [Google Scholar]

26. Mahesh R, Bhuvana S, Begum VM. Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats. Cell Biochem Funct. 2009;27(6):358–363. [PubMed] [Google Scholar]

27. Hazra B, Sarkar R, Biswas S, Mandal N. Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis. BMC Comp Alter Med. 2010;10:20. [PMC free article] [PubMed] [Google Scholar]

28. Lee HS, Won NH, Kim KH, Lee H, Jun W, Lee KW. Antioxidant effects of aqueous extract of Terminalia chebula in vitvo and in vitro. Biol Pharm Bull. 2005;28(9):1639–1644. [PubMed] [Google Scholar]

29. Lee HS, Jung SH, Yun BS, Lee KW. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007;81(3):211–218. [PubMed] [Google Scholar]

30. Chen X, Sun F, Ma L, Wang J, Qin H, Du G. In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit. Indian J Pharmacol. 2011;43(3):320–323. [PMC free article] [PubMed] [Google Scholar]

31. Saleem M, Hushum P, Harkonen K, Pihlaja Inhibition of cancer cell growth by crude extract and phenolics of Terminalia chebula fruit. J Ethnopharmacol. 2002;81:327–336. [PubMed] [Google Scholar]

32. Reddy DB, Reddy TC, Jyotsna G, Sharan S, Priya N, Lakshmipathi V, et al.et al. Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line. J Ethnopharmacol. 2009;124(3):506–512. [PubMed] [Google Scholar]

33. Grover IS, Bala S. Antimutagenic activity of Terminalia chebula (myroblan) in Salmonella typhimurium. Indian J Exp Biol. 1992;30(4):339–341. [PubMed] [Google Scholar]

34. Gandhi NM, Nayar CKK. Radiation protection by Terminalia chebula some mechanistic aspects. Mol Cell Biochem. 2005;277(1–2):43–48. [PubMed] [Google Scholar]

35. Prasad L, Husain Khan T, Jahengir T, Sultana S. Chemomodulatory effect of Terminalia chebula against nickel chloride-induced oxidative stress and tumor promotion response in male Wistar rats. J Trace Elem Med Biol. 2006;20(4):233–239. [PubMed] [Google Scholar]

36. Lee HS, Jung SH, Yun BS, Lee KW. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007;31(3):211–218. [PubMed] [Google Scholar]

37. Tasduq SS, Singh AK, Salti NK, Gupta DK, Suri K. Terminalia chebula fruits prevent liver toxicity caused by sub-chronic adminstration of refampicin, isoniazid and pyrazinamide (PZA) in combination. Hum Exp Toxicol. 2006;25(3):11–18. [Google Scholar]

38. Tasaduq SA, Singh K, Sethi S, Sharma SC, Bedi KL, Singh J, et al.et al. Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine. Hum Exp Toxicol. 2003;22(12):639–645. [PubMed] [Google Scholar]

39. Suchalatha S, Shyamadevi CS. Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol. Indian J Exp Biol. 2004;42(2):174–178. [PubMed] [Google Scholar]

40. Reddy VRC. Cardioprotective activity of the fruit of Terminalia chebula. Fitoterapia. 1990;61:517–525. [Google Scholar]

41. Chang CL, Lin CS, Lai GH, Chen YH, Tuan WC, Hsu CM. Influence of Terminalia chebula extracts on the effect of PC12 cell growth. J Trad Med. 2010;21(1):23–30. [Google Scholar]

42. Minkyun NA, Wan BAE, Kang SS, Min BS, Yoo JK, Yuk OK, et al.et al. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminialia chebula fruit. Phytother Res. 2004;18:737–741. [PubMed] [Google Scholar]

43. Lee HS, Koo YC, Suh HJ, Kim KY, Lee KW. Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction. J Ethnopharmacol. 2010;131(3):567–574. [PubMed] [Google Scholar]

44. Na M, Bae M, Keng SS, Min BS, Yoo JK, Kamiryo Y, et al.et al. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit. Phytother Res. 2004;18(9):737–741. [PubMed] [Google Scholar]

45. Kannan VR, Rajasekar GS, Rajesh P, Balasubramanian V, Ramesh N, Solomon EK, et al.et al. Anti-diabetic activity on ethanolic extracts of fruits of Terminalia chebula Retz. Alloxan induced diabetic rats. Am J Drug Discov Dev. 2012;2:135–142. [Google Scholar]

46. Senthilkumar GP, Subramanian SP. Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats. J Appl Biomed. 2008;6:105–115. [Google Scholar]

47. Khan KH, Jain SK. Regular intake of Terminalia chebula can reduce the risk of getting typhoid fever. Adv Biotech. 2009;8(9):10–15. [Google Scholar]

48. Khan KH. The effect of regular intake of Terminalia chebula on oxidative stress in mice originated from Salmonella typhimurium. EurAsia J BioSci. 2009;3:113–121. [Google Scholar]

49. Malckzadeh F, Ehsanifar H, Shahamat N, Levin M, Colwell RR. Antibacterial activity of black myrobalan (Terminalia chebula Retz.) against Helicobactor pyroli. Int J Antimicrob Agent. 2001;18(1):85–88. [PubMed] [Google Scholar]

50. Kim HG, Cho JH, Jeong EY, Lim JH, Lee SH, Lee HS. Growth inhibitory activity of active component from Terminalia chebula fruits against intestinal bacteria. J Food Prot. 2006;69(9):2205–2209. [PubMed] [Google Scholar]

51. Sato Y, Oketani H, Singyouchi K, Ohtsubo T, Kihara M, Shibata H, et al.et al. Extraction and purification of effective antimicrobial constituents of Terminalia chebula Retz. against methicillin- resistant Staphylococcus aureus. Bull Pharm Bull. 1997;20(4):401–404. [PubMed] [Google Scholar]

52. Bonjar GH. Antibacterial screening of plants used in Iranian folkloric medicine. Fitoterapia. 2004;75(2):231–235. [PubMed] [Google Scholar]

53. Aneja KR, Joshi R. Evaluation of antimicrobial properties of fruit extracts of Terminalia chebula against dental caries pathogens. Jundishapur J Microbiol. 2009;2(3):105–111. [Google Scholar]

54. Kannan P, Ramadevi SR, Hopper W. Antibacterial activity of Terminalia chebula fruit extract. Afr J Microbiol Res. 2009;3(4):180–184. [Google Scholar]

55. Rani P, Khullar N. Antimicrobial evaluation of some medicinal plants for their antienteric potential against multi-drug resistant Salmonella typhi. Phytother Res. 2004;18(8):670–673. [PubMed] [Google Scholar]

56. Agrawal A, Gupta A, Choudhary NK, Wadhwa S, Dav K, Goyal S, et al.et al. Antibacterial activity of hydroalcoholic extract of Terminalia chebula Retz. on different Gram-positive and Gram-negative Bacteria. Int J Pharm Biol Arch. 2010;1(4):485–488. [Google Scholar]

57. Bag A, Bhattacharyya SK, Bharati P, Pal NK, Chattopadhyay RR. Antibacterial activity of Chebulic myrobalan (fruit of Terminalia chebula Retz.) extracts against methicillin resistant Staphylococcus aureus and trimethoprim-sulphamethoxazole resistant uropathogenic Escherichia coli. Afr J Plant Sci. 2009;3(2):25–29. [Google Scholar]

58. Bag A, Bhattacharyya SK, Pal NK, Chattopadhyay RR. Synergistic effect of Terminalia chebula against multidrug-resistant uropathogenic Escherichia coli. Med Aromatic Plant Sci Biotech. 2011;5(1):70–73. [Google Scholar]

59. Barazani VO, Sathiyomoorthy P, Shalev R, Vardy D, Golan GA. Screening of South-Indian medicinal plants for anti-fungal activity. Phyther Res. 2003;17(9):1123–1125. [PubMed] [Google Scholar]

60. Dutta BK, Rahman I, Das TK. Antifungal activity of Indian plant extracts. Mycoses. 1998;41(11–12):535–536. [PubMed] [Google Scholar]

61. Mehmood Z, Ahmad I, Mohammad F, Ahmad S. Indian medicinal plants: A potential source of anticandidal Drugs. Pharm Biol. 1999;37(3):237–242. [Google Scholar]

62. Bonjar GH. Inhibition of Clotrimazole-resistant Candida albicans by plants used in Iranian folkloric medicine. Fitoterapia. 2004;75(1):74–76. [PubMed] [Google Scholar]

63. Jeong AHN, Kim CY, Lee JS, Kim TG, Kim SH, Lee CK, et al.et al. Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flovonol glycoside gallates from Euphorbia pekinensis. Plant Med. 2002;68:457–459. [PubMed] [Google Scholar]

64. Lee D, Boo K, Woo J, Duan F, Lee K, Kwon T, et al.et al. Anti- bacterial and Anti-viral activities of extracts from Terminalia chebula barks. J Korean Soc Appl Biol Chem. 2011;54(2):295–298. [Google Scholar]

65. Badmaev V, Nowakowski M. Protection of epithelial cells against influenza A virus by plant derived biological response modifier Ledretan-96. Phytother Res. 2000;44(4):245–249. [PubMed] [Google Scholar]

66. Gambari R, Lampronti L. Inhibition of immunodeficiency type-1 virus (HIV-1) life cycle by medicinal plant extracts and plant derived compounds. Adv Phytomed. 2006;2:299–311. [Google Scholar]

67. Kurowa M, Nagasaka K, Hirabayashi T, Uyama S, Sato H, Kagiyama T, et al.et al. Efficacy of traditional herbal medicines in combination with acyclovir against Herpes Simplex Virus-1 infection in vitro and in vitvo. Antiviral Res. 1995;27(1–2):19–37. [PubMed] [Google Scholar]

68. Yukawa TA, Kurokawa M, Sato S, Yoshida Y, Kageyamer S, Hasegawa T, et al.et al. Prophylactic treatment of cytomagalovirus infection with traditional herbs. Antiviral Res. 1996;32(2):63–70. [PubMed] [Google Scholar]

69. Vermani K, Garg S. Herbal medicines for sexually transmitted diseases and AIDS. J Ethnopharmacol. 2002;80:49–66. [PubMed] [Google Scholar]

70. Ma H, Zhao YD, Li K, Kang T. A new alternative to treat swine influenza A virus infection: Extracts from Terminalia chebula Retz. Afr J Microbiol Res. 2010;4(6):497–499. [Google Scholar]

71. Dwivedi S, Dwivedi A, Kapadia R, Kaul S. Anthelmintic activity of alcoholic and aqueous extract of fruits of Terminalia chebula Retz. Ethnobot Leaflets. 2008;12:741–743. [Google Scholar]

72. Sohni YR, Kaimal P, Bhatt RM. The antiamoebic effect of crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vitvo. J Ethnopharmacol. 1995;45(1):43–52. [PubMed] [Google Scholar]

73. Bagavan A, Rahuman Al, Kamaraj C, Kaushik NK, Mohanakrishnan D, Sahal D. Antiplasmodial activity of botanical extracts against Plasmodium falciparum. Parasitol Res. 2011;108(5):1099–1109. [PubMed] [Google Scholar]

74. Moeslinger T, Friedl R, Volf I, Brunner M, Koller E, Spieckermann PG. Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. Can J Physiol Pharmacol. 2000;78(11):861–866. [PubMed] [Google Scholar]

75. Nair V, Singh S, Gupta YK. Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models. J Pharm Pharmacol. 2010;62(12):1801–1806. [PubMed] [Google Scholar]

76. Pratibha N, Saxena VS, Amit A, D'Souza P, Bagchi M, Bagchi D. Anti-inflammatory activities of Aller-7, a novel polyherbal formulation for allergic rhinitis. Int J Tissue React. 2004;26(1–2):43–51. [PubMed] [Google Scholar]

77. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six Rasayana herbs used in Ayurvedic medicines. Phytother Res. 1999;13:275–291. [PubMed] [Google Scholar]

78. Shin TY, Jeong HG, kim DK, Kim SH, Lee JK, Chae BS, et al.et al. Inhibitory action of water soluble fraction of Terminalia chebula on systematic and local anaphylaxis. J Ethnopharmacol. 2001;74:133–140. [PubMed] [Google Scholar]

79. Maruthappan V, Shree KS. Hypolipidemic activity of Haritaki (Terminalia chebula) in atherogenic diet induced hyperlipidemic rats. J Adv Pharm Tech Res. 2010;1:229–235. [PMC free article] [PubMed] [Google Scholar]

80. Israni DA, Patel KV, Gandhi TR. Anti-hyperlipidemic activity of aqueous extract of Terminalia chebula and Gaumutra in high cholesterol diet fed rats. Int J Pharm Sci. 2010;1(1):48–59. [Google Scholar]

81. Tamhane MD, Thorate SP, Rege NN, Dahanukar SA. Effect of oral administration of Terminalia chebula on gastric emptying: An experimental study. J Postgrad Med. 1997;43(1):12–13. [PubMed] [Google Scholar]

82. Sharma P, Prakash T, Kotresha D, Ansari MA, Sahrm UR, Kumar B, et al.et al. Antiulcerogenic activity of Terminalia chebula fruit in experimentally induced ulcer in rats. Pharm Biol. 2011;49(3):262–268. [PubMed] [Google Scholar]

83. Seyyed AM, Ali V, Mohammad KGN, Peyman M. Spasmogenic activity of the seed of Terminalia chebula Retz in rat small intestine: In vitvo and in vitro studies. Malays J Med Sci. 2011;18(3):18–26. [PMC free article] [PubMed] [Google Scholar]

84. Carounanidy U, Satyanarayanan R, Velmurugan A. Use of an aqueous extract of Terminalia chebula as an anticaries agent: a clinical study. Indian J Dent Res. 2007;18(4):152–156. [PubMed] [Google Scholar]

85. Li K, Diao Y, Zhang H, Wang S, Zhang Z, Yu B, et al.et al. Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats. BMC Comp Alter Med. 2011;11:1–9. [PMC free article] [PubMed] [Google Scholar]

86. Vani T, Rajani M, Sarkar S, Shishoo CJ. Antioxidant properties of ayurvedic formulation triphala and its constituents. Int J Pharmacog. 1997;35:313–317. [Google Scholar]

87. Aher VD. Immunomodulatory effect of alcoholic extract of Terminalia chebula ripe fruits. J Pharm Sci Res. 2010;2(9):539–544. [Google Scholar]

88. Mukherjee P, Roy S, Bhattacharyya S, Debnath PK, Jan U, Pandit S, et al.et al. Clinical study of Triphala- a well known phytomedicine from India. Indian J Pharmcol Ther. 2006;5:51–54. [Google Scholar]

89. Singh RH, Sinha BN. Clinical and physiological studies on the effect of an indigenous compound Rasayana drug in apparently normal aged person. J Res Indian Med Yoga hom*oeo. 1978;13:1–8. [Google Scholar]

90. Amit VS, Saxena N, Prativa M, Bagchi D, Bagchi J. Safety of novel botanical extract formula for ameliorating allergic rhinitis. Toxicol Mechanisms Methods. 2004;13(4):253–261. [PubMed] [Google Scholar]

91. Panunto W, Jaijoy K, Lerdvuthisopon N, Lertprasertsuke N, Jiruntanat N, Soonthornchareonnon N, et al.et al. Acute and chronic toxicity studies of the water extract from dried fruits of Terminalia chebula Rezt. in rats. Int J Appl Res Nat Prod. 2011;3(4):36–43. [Google Scholar]

92. Ji-hoon K, Yun-chang K, Chung-Oui H, Sung-Yong Y, Woojin J, Lee K. Mutagenicity and oral toxicity studies of Terminalia chebula. Phytother Res. 2012;26:39–47. [PubMed] [Google Scholar]

93. Ponnusankar S, Pandit S, Venkatesh M, Bandyopadhyay A, Mukherjee PK. Cytochrome P450 inhibition assay for standardized extract of Terminaliachebula Retz. Phytother Res. 2011;25(1):151–154. [PubMed] [Google Scholar]

94. Arora S, Brits E, Kaur S, Kaur K, Sohi RS, Kumar S, et al.et al. Evaluation of genotoxicity of medicinal plant extracts by the Comet and VITOTOX tests. J Environ Pathol Toxicol Oncol. 2005;24(3):193–200. [PubMed] [Google Scholar]

95. Rathore HS, Makwama M. Prevention of lead toxicity in Allium cepa root tip cells withmyrobalan (fruit of Terminalia chebula Retz.) Biochem Cell Arch. 2005;5(2):169–176. [Google Scholar]

96. Rathore HS, Shazia B, Sharma A, Makwana M. Prevention of aluminium chloride- induced mitodepression with myrobalan (fruit of Terminalia chebula Retz, Combretaceae) in Allium cepa model. Ethnobot leaflets. 2006;10:272–279. [Google Scholar]

The development of Terminalia chebula Retz. (Combretaceae) in clinical research (2024)
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