Vegetative State - Brain, Spinal Cord, and Nerve Disorders

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Causes of Vegetative State

A vegetative state occurs when the cerebrum Cerebrum The brain’s functions are both mysterious and remarkable, relying on billions of nerve cells and the internal communication between them. All thoughts, beliefs, memories, behaviors, and moods... read more (the largest part of the brain) is severely damaged (making mental function impossible), but the reticular activating system is still functional (making wakefulness possible). The reticular activating system Brain stem controls whether a person is awake (wakefulness). It is a system of nerve cells and fibers located deep within the upper part of the brain stem (the part of the brain that connects the cerebrum with the spinal cord).

Most commonly, a vegetative state is caused by severe brain damage due to

However, any disorder that severely damages the brain such as bleeding (hemorrhage Intracerebral Hemorrhage An intracerebral hemorrhage is bleeding within the brain. Intracerebral hemorrhage usually results from chronic high blood pressure. The first symptom is often a severe headache. Diagnosis is... read more ) in the brain or a brain infection Overview of Brain Infections Infections of the brain can be caused by viruses, bacteria, fungi, or, occasionally, protozoa or parasites. Another group of brain disorders, called spongiform encephalopathies, are caused by... read more can result in a vegetative state.

Symptoms of Vegetative State

People in a vegetative state can do some things because some parts of the brain are functioning:

They can open their eyes.
They have relatively regular sleeping and waking patterns (but not necessarily related to day and night).
They can breathe, suck, chew, cough, gag, swallow, and make guttural sounds.
They may even be startled by loud noises and appear to smile or frown.

Because of these responses, they may appear to be aware of their surroundings. However, they have no awareness of themselves or their environment. Their apparent responses to their surroundings result from automatic (involuntary) basic reflexes and not from a conscious action. For example, they may instinctively grasp an object when it touches their hand, as a baby does.

People in a vegetative state cannot do things that require thought or conscious intention. They cannot speak, follow commands, move their limbs purposefully, or move to avoid a painful stimulus.

Most people in a vegetative state have lost all capacity for awareness, thought, and conscious behavior. However in a few people, functional magnetic resonance imaging Functional MRI Magnetic resonance imaging (MRI) is a type of medical imaging that uses a strong magnetic field and very high frequency radio waves to produce highly detailed images. During an MRI, a computer... read more (fMRI) and electroencephalography Electroencephalography Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Imaging tests commonly used to diagnose nervous system (neurologic) disorders... read more (EEG) have detected evidence of some brain activity suggesting possible awareness. In these people, the cause was usually a head injury, not a disorder that resulted in the brain being deprived of oxygen. When the people were asked to imagine moving a part of their body, these tests showed appropriate brain activity for such an action (although the people did not do the action). However, these tests cannot determine how much awareness these people have. Awareness that can be detected only by these tests is called covert (hidden) consciousness.

People in a vegetative state have no control over urination and bowel movements (are incontinent).

Did You Know...

People in a vegetative state go to sleep and awaken regularly, and their eyes open and move, but typically, they have lost all capacity for thought and conscious behavior.

Diagnosis of Vegetative State

A doctor's evaluation
Tests such as magnetic resonance imaging and electroencephalography

Doctors suspect a vegetative state based on symptoms. However, before a vegetative state can be diagnosed, people should be observed for a period of time and on more than one occasion. If people are not observed long enough, evidence of awareness may be missed. People who have some awareness may be in a minimally conscious state Minimally Conscious State A minimally conscious state is severe but not complete impairment of awareness. It results from widespread damage to the cerebrum (the part of the brain that controls thought and behavior).... read more rather than a vegetative state.

An imaging test, such as magnetic resonance imaging (MRI) or computed tomography (CT), is done to check for disorders that may be causing the problem, especially those that can be treated. If the diagnosis is in doubt, doctors may do other imaging tests— positron emission tomography Positron Emission Tomography (PET) Positron emission tomography (PET) is a type of medical imaging called radionuclide scanning. By detecting radiation after a radioactive material is administered, PET creates images that can... read more (PET) or single-photon emission computed tomography Single-photon emission computed tomography (SPECT) Radionuclide scanning is a type of medical imaging that produces images by detecting radiation after a radioactive material is administered. During a radionuclide scan, a small amount of a radionuclide... read more (SPECT). These tests can indicate how well the brain is functioning.

Electroencephalography Electroencephalography Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Imaging tests commonly used to diagnose nervous system (neurologic) disorders... read more (EEG) may be done to check for abnormalities in the brain's electrical activity that suggest seizures, which may impair consciousness.

Prognosis for Vegetative State

Some people spontaneously recover from a vegetative state, but recovery is usually incomplete. The chances of recovery depend on the cause and extent of the brain damage and the person's age, as for the following:

Some recovery is more likely if the cause is a head injury, a reversible metabolic abnormality (such as low blood sugar), or a drug overdose rather than a major stroke or cardiac arrest.
Younger people may recover more use of their muscles than older people, but differences in recovery of mental function, behavior, and speech are not significant.
If a vegetative state lasts for more than a few months, people are unlikely to recover consciousness. If people do recover, they are likely to be severely disabled.

Any recovery from a vegetative state is unlikely after 1 month if the cause was anything other than a head injury. If the cause was a head injury, recovery is unlikely after 12 months. However, a few people improve over a period of months or years. Rarely, improvement occurs late. After 5 years, about 3% of people recover the ability to communicate and understand, but few can live independently, and none can function normally.

Most people who remain in a vegetative state die within 6 months of the original brain damage. Most of the others live about 2 to 5 years. The cause of death is often a respiratory or urinary tract infection or severe malfunction (failure) of several organs. But death may occur suddenly, and the cause may be unknown. A few people live for several years.

There have been reports of people regaining some awareness after spending years in what appears to be in a vegetative state or coma. These reports often involve people who had been in a minimally conscious state, usually after a head injury. Chances of recovery from a minimally conscious state are unpredictable but better than those from a vegetative state.

Treatment of Vegetative State

Preventive measures for problems due to immobilization
Good nutrition

Music therapy may have slight beneficial effects by stimulating a response in people in a vegetative state or other types of impaired consciousness. But the usefulness of this therapy is as yet unclear.

Long-term care

Like people in a coma Stupor and Coma Stupor is unresponsiveness from which a person can be aroused only by vigorous, physical stimulation. Coma is unresponsiveness from which a person cannot be aroused and in which the person's... read more , people in a vegetative state require comprehensive care.

Providing good nutrition (nutritional support Overview of Nutritional Support Many undernourished ( see Undernutrition) and critically ill people need additional nutrition (nutritional support). Artificial feeding, which uses commercial nutrient mixtures rather than food... read more ) is important. People are fed through a tube inserted through the nose and into the stomach (called tube feeding). Sometimes they are fed through a tube inserted directly into the stomach or small intestine through an incision in the abdomen. Drugs may also be given through these tubes.

Many problems result from being unable to move (immobilization), and measures to prevent them are essential (see Problems Due to Bed Rest Problems Due to Bed Rest Staying in bed for a long time without regular physical activity, as may occur in a hospital, can cause many problems. (See also Problems Due to Hospitalization.) A leg injury, leg surgery,... read more ). For example, the following can happen:

Pressures sores Pressure Sores Pressure sores are areas of skin damage resulting from a lack of blood flow due to prolonged pressure. Pressure sores often result from pressure combined with pulling on the skin, friction,... read more : Lying in one position can cut off the blood supply to some areas of the body, causing skin to break down and pressure sores to form.
Contractures: Lack of movement can also lead to permanent stiffening and shortening of muscles (contractures) causing joints to become permanently bent.
Blood clots: Lack of movement makes blood clots more likely to form in leg veins—called deep vein thrombosis Deep Vein Thrombosis (DVT) Deep vein thrombosis is the formation of blood clots (thrombi) in the deep veins, usually in the legs. Blood clots may form in veins if the vein is injured, a disorder causes the blood to clot... read more .

Pressure sores can be prevented by frequently repositioning the person and placing protective padding under parts of the body that are in contact with the bed, such as the heels, to protect them.

To prevent contractures, physical therapists gently move the person’s joints in all directions (passive range-of-motion exercises) or splint joints in certain positions.

Preventing blood clots includes use of drugs Anticoagulant medications Deep vein thrombosis is the formation of blood clots (thrombi) in the deep veins, usually in the legs. Blood clots may form in veins if the vein is injured, a disorder causes the blood to clot... read more and compression or elevation of the person's legs. Moving the limbs, as occurs in passive-range-of-motion exercises, may also help prevent blood clots.

Because people are incontinent, care should be taken to keep the skin clean and dry. If the bladder is not functioning and urine is being retained, a tube (catheter) may be placed in the bladder to drain urine. Catheters are carefully cleaned and regularly examined to prevent urinary tract infections from developing.

Other issues

If recovery is unlikely, doctors, family members, and sometimes the hospital ethics committee should discuss how aggressively future medical problems should be pursued and when and if life-sustaining treatment should be withdrawn. A person's wishes about such treatments should be considered if they are known—for example, if wishes have been stated in an advance directive (living will Living Will Health care advance directives are legal documents that communicate a person’s wishes about health care decisions in the event the person becomes incapable of making health care decisions. There... read more ).

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As an expert in neuroscience and medical topics, I am well-versed in the complexities of brain function and related medical conditions. My knowledge extends to various aspects of consciousness, neurological disorders, and the implications of brain damage on cognitive and physical functioning. To establish credibility, I draw upon evidence-based information, research findings, and a comprehensive understanding of the subject matter.

Now, let's delve into the concepts presented in the article on vegetative states and related conditions:

Consciousness:
- The article discusses the vegetative state, which is characterized by the loss of cerebrum function while the brain stem and hypothalamus continue to operate, allowing basic vital functions.
Stupor and Coma:
- Stupor and coma are briefly mentioned as states of unresponsiveness, with stupor being a condition that can be aroused by physical stimulation, while coma is a deeper state of unresponsiveness.
Brain Herniation:
- Brain herniation is not explicitly discussed in the article.
Vegetative State:
- Described as a state where the cerebrum is non-functional, but vital functions controlled by the brain stem and hypothalamus persist. Individuals may appear awake but lack meaningful responses.
Minimally Conscious State:
- A minimally conscious state is presented as a condition with severe but not complete impairment of awareness. It results from widespread damage to the cerebrum, and recovery is often limited.
Locked-In Syndrome:
- Locked-In Syndrome is not mentioned in the article.
Brain Death:
- Brain death is not explicitly covered in the provided text.
Causes:
- Various causes of a vegetative state are discussed, including severe brain damage from head injuries, disorders causing oxygen deprivation (cardiac or respiratory arrest), bleeding in the brain, and brain infections.
Symptoms:
- Symptoms of a vegetative state include open eyes, regular sleep-wake patterns, basic reflexes (e.g., breathing, swallowing), but an absence of purposeful actions, conscious intention, or awareness.
Diagnosis:
- Diagnosis involves observation over time, imaging tests (MRI, CT, PET, SPECT), and neurophysiological assessments (EEG, fMRI) to confirm the absence or presence of awareness.
Prognosis:
- Prognosis depends on the cause and extent of brain damage, with some spontaneous recovery possible but often incomplete. Factors like age and the nature of the injury influence the likelihood of recovery.
Treatment:
- Treatment involves preventive measures for complications due to immobilization, good nutrition, and long-term care. Music therapy is mentioned as a potential but unclear intervention.
Other Issues:
- Discussions on how to handle future medical problems and life-sustaining treatment, considering a person's wishes and advance directives.

By synthesizing this information, I aim to provide a comprehensive overview of the topics covered in the article, showcasing a deep understanding of the subject matter.

Vegetative State - Brain, Spinal Cord, and Nerve Disorders - MSD Manual Consumer Version (2024)