Toxicology test | Drug Screening, Poison Detection & Clinical Analysis (2024)

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toxicology test, any of a group of laboratory analyses that are used to determine the presence of poisons and other potentially toxic agents in blood, urine, or other bodily substances. Toxicology is the study of poisons—their action, their detection, and the treatment of conditions they produce. Many substances are toxic only at high concentrations. For example, lithium is used to treat bipolar disorder but can be toxic at high levels. Another example is acetaminophen, which is valuable in controlling fever and discomfort but is toxic in large doses. A single toxicology screen may test for as many as 30 agents at one time.

The concentration of an element in the blood is the usual measure of toxicity. The therapeutic blood range is the concentration of the drug that provides therapeutic benefit, whereas the toxic blood range is the concentration at which toxic manifestations are likely. Some substances such as insecticides are toxic to one individual and not to another. Many environmental substances as well as some encountered in the workplace are toxic in high doses; these include organic solvents, heavy metals, mineral dusts, dyes, and cigarette smoke. Acceptable exposure levels are controlled by government standards.

Toxicology test | Drug Screening, Poison Detection & Clinical Analysis (1)

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Biology Bonanza

The nervous system is most sensitive to toxicological damage. Common toxins that cause damage to peripheral nerves are the six-carbon solvents, such as n-hexane, found in glues or solvents and organophosphorus compounds. Carbon disulfide, used in the production of rayon fibres and cellophane, is a potent neurotoxin. Because no specific treatment is available for most of these toxic manifestations, preventing overexposure is important.

This article was most recently revised and updated by Kara Rogers.

Toxicology test | Drug Screening, Poison Detection & Clinical Analysis (2024)

FAQs

What are the results of a toxicology test? ›

What Do the Results of a Toxicology Screen Mean? Most toxicology screens provide limited information about how much or how often someone has taken a drug. The results of a toxicology screen are usually positive or negative. A positive test result means that a drug or multiple drugs are present in the body.

How accurate are toxicology reports? ›

While a toxicology report can determine if someone consumed a substance, it cannot always accurately reflect when the drug was taken or whether someone was intoxicated. That determination is dependent upon a person's metabolism, their tolerance of a drug from potential prior use and a multitude of other factors.

What does a toxicology screening test for? ›

A toxicology screen refers to various tests that determine the type and approximate amount of legal and illegal drugs a person has taken by measuring how much is in their blood, urine, or other bodily fluid.

What is a toxicology screen for poison? ›

This test is often done in emergency medical situations. It can be used to evaluate possible accidental or intentional overdose or poisoning. It may help determine the cause of acute drug toxicity, monitor drug dependency, and determine the presence of substances in the body for medical or legal purposes.

How long do toxicology results take? ›

Forensic toxicology (in Medical Examiner Office cases) is very different from the drug testing performed in hospitals. Toxicology analysis may only take 4 to 6 weeks if no drugs are present; however, 6 to 8 weeks are typically required to perform the necessary confirmations and quantitations of drugs detected.

What would toxicology analyze? ›

The Toxicology Unit identifies and quantifies (determines the amounts of) drugs, alcohols, and poisons in biological samples such as blood, urine, or tissue. The information is used by law enforcement and the courts to help determine if laws have been broken and/or if criminal charges are warranted.

How long does it take for a toxicology screen to come back? ›

Popular “crime scene investigation” television programs are able to complete toxicology reports in a very short (and unrealistic) time frame. In reality, while an autopsy is usually completed within a day or two after a death, the final results of the toxicology report may take four to six weeks or longer.

What drugs show up in a tox screen? ›

Five drugs commonly tested in the United States in a urine screen are:
  • Cocaine.
  • Amphetamines.
  • Marijuana.
  • Phencyclidine (PCP)
  • Opioids.

What types of samples can be collected for toxicology analysis? ›

For potential toxicologic investigation, collect the following:
  • Brain.
  • Liver, without gall bladder.
  • Kidney.
  • Fat.
  • Urine.
  • Aqueous humor or intact eyeball (preferred)
  • Skin (site of exposure)
  • Heart blood (collected into heparinized tube/green top Vacutainer)

What is the most common toxicology test? ›

Urine drug testing (UDT): This is the most common drug test. It requires a sample of your urine (pee). Urine drug tests are most commonly used to detect alcohol, amphetamines, benzodiazepines, opiates/opioids, cocaine and marijuana (THC).

How to test for toxicity in the body? ›

Blood, urine, and hair analysis can all provide different insights into various aspects of toxicity. Comprehensive stool testing may also be beneficial to assess an individual's ability to properly eliminate toxins.

How much is a toxicology report? ›

Experts in blood analysis need to use expensive instruments for analysis. Expect fees from $2,500-$5,000, which will include a report and perhaps a deposition/court appearance.

What does a full toxicology report show? ›

A typical toxicology report will list and detail: The samples used: hair, blood, urine, and/or other bodily fluids, and stomach contents (in the case of an autopsy)

What are the 5 signs and symptoms of poisoning? ›

Signs or symptoms of poisoning may include:
  • Very large or very small pupils.
  • Rapid or very slow heartbeat.
  • Rapid or very slow breathing.
  • Drooling or very dry mouth.
  • Stomach pain, nausea, vomiting, or diarrhea.
  • Sleepiness or hyperactivity.
  • Confusion.
  • Slurred speech.

Can a toxicology report be wrong? ›

In rare instances, the death certificate may need to be amended if the subsequent toxicologic analysis demonstrates that the rapid screening test was a false negative. Postmortem alterations result in qualitative as well as quantitative changes to toxicological findings (15-20).

How do they do a toxicology report after death? ›

In the typical autopsy, fluids and tissue samples are collected specifically for toxicology testing. The types of samples collected from the body, and the testing targets in these biological fluids and tissues, are determined by circ*mstances of the case and the condition of the body.

Why would a doctor order a toxicology report? ›

Toxicological screens take place for various reasons, including a forensic investigation, rape, use of illicit drugs, and drug overdose. While consent is recommended before such testing, some patients may not be able to provide consent for whatever reason.

How long does it take to determine the cause of death? ›

Autopsy reports are usually completed within 60 days from the date of autopsy; however, there are cases which can take 90 days or longer depending on the complexity of the case.

How far back does a toxicology test go? ›

In general, the detection time is longest in hair, followed by urine and oral fluid. Drugs in hair may be detectable for approximately 90 days, whereas drugs in urine are generally detectable for one to seven days or longer in chronic users and in oral fluid from five to 48 hours.

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