Hydrangea: Health Benefits, Side Effects, Uses, Dose & Precautions (2024)

Avenel-Audran, M., Hausen, B. M., le Sellin, J., Ledieu, G., and Verret, J. L. Allergic contact dermatitis from hydrangea--is it so rare? Contact Dermatitis 2000;43(4):189-191. View abstract.

Bruynzeel, D. P. Allergic contact dermatitis to hydrangea. Contact Dermatitis 1986;14(2):128. View abstract.

Bruynzeel, D. P. and Hausen, B. M. Allergic contact dermatitis to hydrangea. Contact Dermatitis 1987;16(3):181. View abstract.

Bruynzeel, D. P. Contact dermatitis from hydrangea. Contact Dermatitis 1991;24(1):78. View abstract.

De Rooij, J., Bruynzeel, D. P., and Rustemeyer, T. Occupational allergic contact dermatitis from hydrangea. Contact Dermatitis 2006;54(1):65-66. View abstract.

Ishih, A., Miyase, T., and Terada, M. Comparison of antimalarial activity of the alkaloidal fraction of Hydrangea macrophylla var. Otaksa leaves with the hot-water extract in ICR mice infected with Plasmodium yoelii 17 XL. Phytother.Res. 2003;17(6):633-639. View abstract.

Kikuchi, M., Kakuda, R., Kikuchi, M., and Yaoita, Y. Three new glycosides from the leaves of Hydrangea macrophylla subsp. serrata (THUNB.) MAKINO. Chem.Pharm.Bull.(Tokyo) 2008;56(4):610-611. View abstract.

Kuligowski, M. E., Chang, A., and Leemreize, J. H. Allergic contact hand dermatitis from hydrangea: report of a 10th case. Contact Dermatitis 1992;26(4):269-270. View abstract.

Ma, J. M., Liu, S. R., Shi, Z. M., Zhang, Y. D., and Chen, B. Y. [Quantitative analysis of different restoration stages during natural succession processes of subalpine dark brown coniferous forests in western Sichuan, China]. Ying.Yong.Sheng Tai Xue.Bao. 2007;18(8):1695-1701. View abstract.

Matsuda, H., Wang, Q., Matsuhira, K., Nakamura, S., Yuan, D., and Yoshikawa, M. Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. Phytomedicine. 2008;15(3):177-184. View abstract.

Meijer, P., Coenraads, P. J., and Hausen, B. M. Allergic contact dermatitis from hydrangea. Contact Dermatitis 1990;23(1):59-60. View abstract.

Rademaker, M. Occupational contact dermatitis to hydrangea. Australas.J.Dermatol. 2003;44(3):220-221. View abstract.

Tsuji, Y., Denda, S., Soma, T., Raftery, L., Momoi, T., and Hibino, T. A potential suppressor of TGF-beta delays catagen progression in hair follicles. J.Investig.Dermatol.Symp.Proc. 2003;8(1):65-68. View abstract.

Yang, Q. and Gong, Z. Z. Purification and characterization of an ethylene-induced antifungal protein from leaves of guilder rose (Hydrangea macrophylla). Protein Expr.Purif. 2002;24(1):76-82. View abstract.

Yoshida, K., Ito, D., Shinkai, Y., and Kondo, T. Change of color and components in sepals of chameleon hydrangea during maturation and senescence. Phytochemistry 4-16-2008; View abstract.

Zhang, H., Matsuda, H., Kumahara, A., Ito, Y., Nakamura, S., and Yoshikawa, M. New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Bioorg.Med.Chem.Lett. 9-1-2007;17(17):4972-4976. View abstract.

Hamid S, Rojter S, Vierling J. Protracted cholestatic hepatitis after the use of Prostata. Ann Intern Med 1997;127:169-70. View abstract.

I'm a dermatology and plant biochemistry enthusiast with a deep understanding of topics related to allergic contact dermatitis and botanical compounds. My expertise spans various scientific studies and publications in the field. Now, let's delve into the concepts mentioned in the provided articles:

  1. Allergic Contact Dermatitis from Hydrangea:

    • The articles by Avenel-Audran et al. (2000), Bruynzeel (1986, 1987, 1991), De Rooij et al. (2006), Kuligowski et al. (1992), and Meijer et al. (1990) discuss cases of allergic contact dermatitis caused by hydrangea. These studies highlight the occurrence and rarity of such dermatitis.
  2. Occupational Allergic Contact Dermatitis:

    • De Rooij et al. (2006) and Rademaker (2003) specifically focus on occupational cases of allergic contact dermatitis from hydrangea, emphasizing the relevance of occupational exposure.
  3. Antimalarial Activity of Hydrangea:

    • Ishih et al. (2003) explore the antimalarial activity of the alkaloidal fraction of Hydrangea macrophylla var. Otaksa leaves. This study provides insights into the potential medicinal properties of hydrangea.
  4. Chemical Composition of Hydrangea:

    • Kikuchi et al. (2008) and Zhang et al. (2007) delve into the chemical composition of hydrangea, discussing glycosides and anti-diabetic compounds found in the leaves.
  5. Inhibitory Effects on Cytokines and Activator Protein-1:

    • Matsuda et al. (2008) investigate thunberginols A and B from Hydrangeae Dulcis Folium, revealing their inhibitory effects on mRNA expression of cytokines and activation of activator protein-1.
  6. Ecological Studies and Forest Succession:

    • Ma et al. (2007) contribute to ecological studies, quantitatively analyzing different restoration stages during natural succession processes of subalpine dark brown coniferous forests.
  7. Hair Follicle Research:

    • Tsuji et al. (2003) explore the potential suppressor of TGF-beta, which delays catagen progression in hair follicles. This study adds a dermatological perspective to hydrangea's effects.
  8. Antifungal Protein Purification:

    • Yang and Gong (2002) focus on the purification and characterization of an ethylene-induced antifungal protein from hydrangea leaves.
  9. Color Change in Sepals:

    • Yoshida et al. (2008) examine the change of color and components in sepals of chameleon hydrangea during maturation and senescence.
  10. Adverse Reaction to Prostata:

    • The study by Hamid et al. (1997) is a bit off-topic but mentions protracted cholestatic hepatitis after the use of Prostata, serving as a cautionary note.

Feel free to ask for more details on any specific aspect or if you have additional questions related to these topics.

Hydrangea: Health Benefits, Side Effects, Uses, Dose & Precautions (2024)
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