Antioxidant and anticancer activities of chamomile (Matricaria recutita L.) (2024)

1. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4:118–126. doi:10.4103/0973-7847.70902. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

2. Aruoma OI. Free radicals, antioxidants and international nutrition. Asia Pac J Clin Nutr. 1999;8:53–63. doi:10.1046/j.1440-6047.1999.00036.x. [PubMed] [CrossRef] [Google Scholar]

3. Gupta VK, Sharma SK. Plants as natural antioxidants. Nat Prod Radiance. 2006;5:326–334. [Google Scholar]

4. Magder S. Reactive oxygen species: toxic molecules or spark of life? Crit Care. 2006;10:208–216. doi:10.1186/cc3992. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

5. Halliwell B. How to characterize an antioxidant: an update. Biochem Soc Symp. 1995;61:73–101. doi:10.1042/bss0610073. [PubMed] [CrossRef] [Google Scholar]

6. Brewer MS. Natural antioxidants: sources, compounds, mechanisms of action, and potential applications. Compr Rev Food Sci Food Saf. 2011;10:221–247. doi:10.1111/j.1541-4337.2011.00156.x. [CrossRef] [Google Scholar]

7. Ebrahimzadeh MA, Pourmorad F, Hafezi S. Antioxidant activities of Iranian corn silk. Turkish J. Biol. 2008;32:43–49. [Google Scholar]

8. Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat Res. 2005;579:200–213. doi:10.1016/j.mrfmmm.2005.03.023. [PubMed] [CrossRef] [Google Scholar]

9. Chaudière J, Ferrari-Iliou R. Intracellular antioxidants: from chemical to biochemical mechanisms. Food Chem Toxicol. 1999;37:949–962. doi:10.1016/S0278-6915(99)00090-3. [PubMed] [CrossRef] [Google Scholar]

10. Fridovich I. Fundamental aspects of reactive oxygen species, or what’s the matter with oxygen? Ann N Y Acad Sci. 1999;893:13–18. doi:10.1111/j.1749-6632.1999.tb07814.x. [PubMed] [CrossRef] [Google Scholar]

11. Hinneburg I, Damien Dorman HJ, Hiltunen R. Antioxidant activities of extracts from selected culinary herbs and spices. Food Chem. 2006;97:122–129. doi:10.1016/j.foodchem.2005.03.028. [CrossRef] [Google Scholar]

12. Carnat A, Carnat AP, Fraisse D, Ricoux L, Lamaison JL. The aromatic and polyphenolic composition of Roman camomile tea. Fitoterapia. 2004;75:32–38. doi:10.1016/j.fitote.2003.07.007. [PubMed] [CrossRef] [Google Scholar]

13. Peña D, de Montes Oca N, Rojas S, Parra A, García G. Anti-inflammatory and anti-diarrheic activity of Isocarpha cubana Blake. Pharmacologyonline. 2006;3:744–749. [Google Scholar]

14. Sebai H, Jabri M-A, Souli A, Rtibi K, Selmi S, Tebourbi O, et al. Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats. J Ethnopharmacol. 2014;152:327–332. doi:10.1016/j.jep.2014.01.015. [PubMed] [CrossRef] [Google Scholar]

15. Zemestani M, Rafraf M, Asghari-Jafarabadi M. Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus. Nutrition. 2016;32:66–72. doi:10.1016/j.nut.2015.07.011. [PubMed] [CrossRef] [Google Scholar]

16. Patel D, Shukla S, Gupta S. Apigenin and cancer chemoprevention: progress, potential and promise. Int J Oncol. 2007;30:233–245. [PubMed] [Google Scholar]

17. Ranpariya V, Parmar S, Sheth N, Chandrashekhar V. Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats. Pharm. Biol. 2011;49:696–701. doi:10.3109/13880209.2010.540249. [PubMed] [CrossRef] [Google Scholar]

18. Chandrashekhar V, Halagali K, Nidavani R, Shalavadi MH, Biradar BS, Biswas D, et al. Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model. J Ethnopharmacol. 2011;137:336–340. doi:10.1016/j.jep.2011.05.029. [PubMed] [CrossRef] [Google Scholar]

19. Silva N, Barbosa L, Seito L, Fernandes Junior A. Antimicrobial activity and phytochemical analysis of crude extracts and essential oils from medicinal plants. Nat Prod Res. 2012;26:1510–1514. doi:10.1080/14786419.2011.564582. [PubMed] [CrossRef] [Google Scholar]

20. Gould L, Reddy CR, Gomprecht RF. Cardiac effects of chamomile tea. J Clin Pharmacol. 1973;13:475–479. [PubMed] [Google Scholar]

21. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 2005;4:206–220. doi:10.1038/nrd1657. [PubMed] [CrossRef] [Google Scholar]

22. Hadley SK, Petry JJ. Medicinal herbs: a primer for primary care. Hosp Pract. 1999;34:105–123. doi:10.3810/hp.1999.06.151. [PubMed] [CrossRef] [Google Scholar]

23. Way T-D, Kao M-C, Lin J-K. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem. 2004;279:4479–4489. doi:10.1074/jbc.M305529200. [PubMed] [CrossRef] [Google Scholar]

24. Srivastava JK, Gupta S. Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells. J Agric Food Chem. 2007;55:9470–9478. doi:10.1021/jf071953k. [PubMed] [CrossRef] [Google Scholar]

25. Srivastava JK, Shankar E, Gupta S. Chamomile: a herbal medicine of the past with bright future. Mol Med Rep. 2010;3:895–901. [PMC free article] [PubMed] [Google Scholar]

26. Singleton VL, Orthofer R, Lamuela-Raventós RM. [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol. 1999;299:152–178. doi:10.1016/S0076-6879(99)99017-1. [CrossRef] [Google Scholar]

27. Lim YY, Quah EPL. Antioxidant properties of different cultivars of Portulaca oleracea. Food Chem. 2007;103:734–740. doi:10.1016/j.foodchem.2006.09.025. [CrossRef] [Google Scholar]

28. Chang C-C, Yang M-H, Wen H-M, Chern J-C. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal. 2002;10:178–182. [Google Scholar]

29. Folkman J, Long DM, Becker FF. Growth and metastasis of tumor in organ culture. Cancer. 1963;16:453–467. doi:10.1002/1097-0142(196304)16:4<453::AID-CNCR2820160407>3.0.CO;2-Y. [PubMed] [CrossRef] [Google Scholar]

30. Al-Dabbagh B, Elhaty IA, Murali C, Madhoon AA, Amin A. Salvadora persica (Miswak): antioxidant and Promising Antiangiogenic Insights. Am J Plant Sci. 2018;09:1228–1244. doi:10.4236/ajps.2018.96091. [CrossRef] [Google Scholar]

31. Al-Salahi OSA, Kit-Lam C, Majid AM, Al-Suede FS, Mohammed SA, Abdullah WZ, et al. Anti-angiogenic quassinoid-rich fraction from Eurycoma longifolia modulates endothelial cell function. Microvasc Res. 2013;90:30–39. doi:10.1016/j.mvr.2013.07.007. [PubMed] [CrossRef] [Google Scholar]

32. Romanelli R, Petrai I, Robino G, Efsen E, Novo E, Bonacchi A, et al. Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells. Am J Physiol Gastrointest Liver Physiol. 2006;290:G120–G128. doi:10.1152/ajpgi.00350.2004. [PubMed] [CrossRef] [Google Scholar]

33. Roby MHH, Sarhan MA, Selim KA-H, Khalel KI. Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare L.) and chamomile (Matricaria chamomilla L.) Ind Crops Prod. 2013;44:437–445. doi:10.1016/j.indcrop.2012.10.012. [CrossRef] [Google Scholar]

34. Robbins RJ. Phenolic acids in foods: an overview of analytical methodology. J Agric Food Chem. 2003;51:2866–2887. doi:10.1021/jf026182t. [PubMed] [CrossRef] [Google Scholar]

35. Wojdyło A, Oszmiański J, Czemerys R. Antioxidant activity and phenolic compounds in 32 selected herbs. Food Che. 2007;105:940–949. doi:10.1016/j.foodchem.2007.04.038. [CrossRef] [Google Scholar]

36. Pontis JA, Costa LA, Silva SJ, Flach A. Color, phenolic and flavonoid content, and antioxidant activity of honey from Roraima, Brazil. Food Sci Technol. 2014;34:69–73. doi:10.1590/S0101-20612014005000015. [CrossRef] [Google Scholar]

37. Formisano C, Delfine S, Oliviero F, Tenore GC, Rigano D, Senatore F. Correlation among environmental factors, chemical composition and antioxidative properties of essential oil and extracts of chamomile (Matricaria chamomilla L.) collected in Molise (South-central Italy) Ind Crops Prod. 2015;63:256–263. doi:10.1016/j.indcrop.2014.09.042. [CrossRef] [Google Scholar]

38. Robards K, Prenzler PD, Tucker G, Swatsitang P, Glover W. Phenolic compounds and their role in oxidative processes in fruits. Food Chem. 1999;66:401–436. doi:10.1016/S0308-8146(99)00093-X. [CrossRef] [Google Scholar]

39. Kitts DD, Wijewickreme AN, Hu C. Antioxidant properties of a North American ginseng extract. Mol Cell Biochem. 2000;203:1–10. doi:10.1023/A:1007078414639. [PubMed] [CrossRef] [Google Scholar]

40. Shan B, Cai YZ, Sun M, Corke H. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J Agric Food Chem. 2005;53:7749–7759. doi:10.1021/jf051513y. [PubMed] [CrossRef] [Google Scholar]

41. Sazegar M, Banakar A, Bahrami N, Bahrami A, Baghbani M, Nematolahi P, et al. Determination of the antioxidant activity and stability of Chamomile (Matricaria chamomilla L.) extract in sunflower oil. World Appl Sci J. 2011;12:1500–1504. [Google Scholar]

42. Amin A, Mousa M. Merits of anti-cancer plants from the Arabian Gulf region. Cancer Ther. 2007;5:55–66. [Google Scholar]

43. Popova M, Bankova V, Butovska D, Petkov V, Nikolova-Damyanova B, Sabatini AG, et al. Validated methods for the quantification of biologically active constituents of poplar-type propolis. Phytochem Anal. 2004;15:235–240. doi:10.1002/pca.777. [PubMed] [CrossRef] [Google Scholar]

44. Amin A, Hamza AA, Bajbouj K, Ashraf SS, Daoud S. Saffron: a potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology. 2011;54:857–867. doi:10.1002/hep.24433. [PubMed] [CrossRef] [Google Scholar]

45. Al-Hrout A, Chaiboonchoe A, Khraiwesh B, Murali C, Baig B, El-Awady R, et al. Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells. Sci Rep. 2018;8(1):16951. doi:10.1038/s41598-018-34855-0. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

46. Ruhul Amin ARM, Karpowicz PA, Carey TE, Arbiser J, Nahta R, Chen ZG, et al. Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Semin Cancer Biol. 2015;35:S55–S77. doi:10.1016/j.semcancer.2015.02.005. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

47. Guimarães R, Barros L, Dueñas M, Calhelha RC, Carvalho AM, Santos-Buelga C, et al. Infusion and decoction of wild German chamomile: bioactivity and characterization of organic acids and phenolic compounds. Food Chem. 2013;136:947–954. doi:10.1016/j.foodchem.2012.09.007. [PubMed] [CrossRef] [Google Scholar]

48. Cavalieri E, Mariotto S, Fabrizi C, de Prati AC, Gottardo R, Leone S, et al. α-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun. 2004;315:589–594. doi:10.1016/j.bbrc.2004.01.088. [PubMed] [CrossRef] [Google Scholar]

49. Matic IZ, Juranic Z, Savikin K, Zdunic G, Nadvinski N, Godevac D. Chamomile and marigold tea: chemical characterization and evaluation of anticancer activity. Phytother Res PTR. 2013;27:852–858. doi:10.1002/ptr.4807. [PubMed] [CrossRef] [Google Scholar]

50. Chatterjee S, Heukamp LC, Siobal M, Schöttle J, Wieczorek C, Peifer M, et al. Tumor VEGF: VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest. 2013;123:1732–1740. doi:10.1172/JCI65385. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

51. Kuwajima A, Iwash*ta J, Murata J, Abe T. The histone deacetylase inhibitor butyrate inhibits melanoma cell invasion of Matrigel. Anticancer Res. 2007;27:4163–4169. [PubMed] [Google Scholar]

52. Sun L-C, Luo J, Mackey LV, Fuselier JA, Coy DH. A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, αVβ3/αVβ5 and MMP-2/-9. Cancer Lett. 2007;246:157–166. doi:10.1016/j.canlet.2006.02.016. [PubMed] [CrossRef] [Google Scholar]

53. Riesterer O, Zingg D, Hummerjohann J, Bodis S, Pruschy M. Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells. Oncogene. 2004;23:4624–4635. doi:10.1038/sj.onc.1207596. [PubMed] [CrossRef] [Google Scholar]

54. Al-Dabbagh B, Elhaty IA, Al Hrout AA, Al Sakkaf R, El-Awady R, Ashraf SS, et al. Antioxidant and anticancer activities of Trigonella foenum-graecum, Cassia acutifolia and Rhazya stricta. BMC Complement Altern Med. 2018;18:240–252. doi:10.1186/s12906-018-2285-7. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Antioxidant and anticancer activities of chamomile (Matricaria recutita L.) (2024)
Top Articles
Latest Posts
Article information

Author: Dr. Pierre Goyette

Last Updated:

Views: 5282

Rating: 5 / 5 (50 voted)

Reviews: 81% of readers found this page helpful

Author information

Name: Dr. Pierre Goyette

Birthday: 1998-01-29

Address: Apt. 611 3357 Yong Plain, West Audra, IL 70053

Phone: +5819954278378

Job: Construction Director

Hobby: Embroidery, Creative writing, Shopping, Driving, Stand-up comedy, Coffee roasting, Scrapbooking

Introduction: My name is Dr. Pierre Goyette, I am a enchanting, powerful, jolly, rich, graceful, colorful, zany person who loves writing and wants to share my knowledge and understanding with you.